The Mystery of the Druids is a single player adventure game released in September 2001. The game itself received very poor reviews. The ridiculous box art, however, gained attention on 4chan, the earliest recorded thread appearing in August of 2007.
(NSFW) http://4chanarchive.org/brchive/dspl_thread.php5?thread_id=37885903&x=the+mystery+of+the+druids#37887103
Much of the appeal comes from the fact that the face does not accurately display any human emotion, despite the intensity of the glare.
Since the initial threads, interest will occasionally spark new photoshop threads, both on 4chan and off:
http://forums.somethingawful.com/showthread.php?threadid=3291841&userid=0&perpage=40&pagenumber=1
The hype has largely died down, but the results of it can still sometimes be seen as reaction faces or in You Laugh You Lose threads.
Google insights: http://www.google.com/insights/search/#q=mystery%20of%20the%20druids%2Cthe%20mystery%20of%20the%20druids&cmpt=q
http://1d4chan.org/wiki/Mystery_of_the_Druids